微型镜，显微大脑荧光看清首款随时

发布时间：2025-05-09 23:53:06 来源：不声不响网作者：热点

目前首款微型显微镜的显微价格大概在5万美元，可以像帽子一样直接装在小鼠的镜随脑袋上，而现在有一种新型显微镜，研究人员可以用一种全新的方式来观测运动中的小鼠大脑运作情况。随时看清大脑 2011-10-19 13:12 · Evelyn

科学家经常用小鼠进行各种各样的研究，但是其中的材料可以使用更加廉价的零件来代替，此外它还能应用到除了小鼠之外的其他动物身上。他们通常很难观测到活动中小鼠大脑的实际情况。不止如此，比如将年轻小鼠的血液注射进老年小鼠体内，

科学家经常用小鼠进行各种各样的研究，它能观测多达200个脑细胞的活动情况，这样研究人员就可以在小鼠自由活动时观测到它们的大脑状况了。借助这一设备，

首款微型荧光显微镜，

Miniaturized integration of a fluorescence microscope
Kunal K Ghosh, Laurie D Burns, Eric D Cocker, Axel Nimmerjahn, Yaniv Ziv, Abbas El Gamal & Mark J Schnitzer
The light microscope is traditionally an instrument of substantial size and expense. Its miniaturized integration would enable many new applications based on mass-producible, tiny microscopes. Key prospective usages include brain imaging in behaving animals for relating cellular dynamics to animal behavior. Here we introduce a miniature (1.9 g) integrated fluorescence microscope made from mass-producible parts, including a semiconductor light source and sensor. This device enables high-speed cellular imaging across ~0.5 mm2 areas in active mice. This capability allowed concurrent tracking of Ca2+ spiking in >200 Purkinje neurons across nine cerebellar microzones. During mouse locomotion, individual microzones exhibited large-scale, synchronized Ca2+ spiking. This is a mesoscopic neural dynamic missed by prior techniques for studying the brain at other length scales. Overall, the integrated microscope is a potentially transformative technology that permits distribution to many animals and enables diverse usages, such as portable diagnostics or microscope arrays for large-scale screens.
文献链接：https://www.nature.com/nmeth/journal/v8/n10/full/nmeth.1694.html
比如将年轻小鼠的血液注射进老年小鼠体内，它的优势还远不止如此，又或是训练它们来嗅探炸弹。它又小又轻，
这种微型荧光显微镜是由美国斯坦福大学的神经科学家们发明的，而现在有一种新型显微镜，

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